When his parents decide to separate, eighth-grader Donnie watches with horror as the physical condition of his sixteen-year old sister, Karen, deteriorates due to an eating disorder.

Months after coming out of alcohol and drug rehab, high school student Nan wakes up on the subway the day after Halloween wearing a torn Halloween costume, her long hair cut, and "HELP ME" scrawled across her chest, feeling sick and having no idea how she got there.